Lactate monitoring in droplet microfluidics: a cautionary tale in assay miniaturisation.

Chi Leng Leong; Sharon Coleman; Adrian M Nightingale; Sammer-Ul Hassan; David Voegeli; Martyn G Boutelle; Xize Niu

doi:10.1039/C9AY02070E

Lactate monitoring in droplet microfluidics: a cautionary tale in assay miniaturisation.

Chi Leng Leong
, Sharon Coleman
, Adrian M Nightingale
, Sammer-Ul Hassan
, David Voegeli
, Martyn G Boutelle
, Xize Niu

School of Health & Care Professions (HCP)

Research output: Contribution to journal › Article › peer-review

Abstract

We present the development of a droplet-based device for real-time continuous lactate measurement, highlighting how protocols from long-established homogeneous enzymatic assays require careful re-optimisation before their migration into miniaturised droplet-based microfluidics.

Original language	English
Pages (from-to)	6119-6123
Journal	Analytical Methods
Volume	11
DOIs	https://doi.org/10.1039/C9AY02070E
Publication status	Published - 18 Nov 2019

Access to Document

10.1039/C9AY02070E

https://eprints.soton.ac.uk/435938/1/Lactate_paper_PostReview2_clean.pdf

Cite this

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title = "Lactate monitoring in droplet microfluidics: a cautionary tale in assay miniaturisation.",

abstract = "We present the development of a droplet-based device for real-time continuous lactate measurement, highlighting how protocols from long-established homogeneous enzymatic assays require careful re-optimisation before their migration into miniaturised droplet-based microfluidics.",

author = "\{Chi Leng Leong\} and \{Sharon Coleman\} and \{Adrian M Nightingale\} and \{Sammer-Ul Hassan\} and David Voegeli and \{Martyn G Boutelle\} and \{Xize Niu\}",

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AU - Chi Leng Leong

AU - Sharon Coleman

AU - Adrian M Nightingale

AU - Sammer-Ul Hassan

AU - Voegeli, David

AU - Martyn G Boutelle

AU - Xize Niu

PY - 2019/11/18

Y1 - 2019/11/18

N2 - We present the development of a droplet-based device for real-time continuous lactate measurement, highlighting how protocols from long-established homogeneous enzymatic assays require careful re-optimisation before their migration into miniaturised droplet-based microfluidics.

AB - We present the development of a droplet-based device for real-time continuous lactate measurement, highlighting how protocols from long-established homogeneous enzymatic assays require careful re-optimisation before their migration into miniaturised droplet-based microfluidics.

U2 - 10.1039/C9AY02070E

DO - 10.1039/C9AY02070E

M3 - Article

SN - 1759-9660

VL - 11

SP - 6119

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JO - Analytical Methods

JF - Analytical Methods

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