TY - CHAP
T1 - Glutamine and the immune system
AU - Marino, Luise V.
AU - Calder, Philip C.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Glutamine is a very important amino acid in supporting the immune response, and it is thought that one of the contributors to impaired immunity in catabolic stress states is a diminished supply of glutamine. The aim of this chapter is to review the metabolism of glutamine by cells of the immune system; the role(s) of glutamine in supporting specic immune cell functions; the evidence from animal models and human clinical trials around glutamine, immunity, infection, and inammation; and the mechanisms of action of glutamine within the immune system, with an emphasis on the role of heat shock proteins. Prior to discussing glutamine, the chapter describes in brief the immune system and its function in health and disease. The effects of glutamine on the immune system in the context of exercise are covered in Chapters 22 and 23.
AB - Glutamine is a very important amino acid in supporting the immune response, and it is thought that one of the contributors to impaired immunity in catabolic stress states is a diminished supply of glutamine. The aim of this chapter is to review the metabolism of glutamine by cells of the immune system; the role(s) of glutamine in supporting specic immune cell functions; the evidence from animal models and human clinical trials around glutamine, immunity, infection, and inammation; and the mechanisms of action of glutamine within the immune system, with an emphasis on the role of heat shock proteins. Prior to discussing glutamine, the chapter describes in brief the immune system and its function in health and disease. The effects of glutamine on the immune system in the context of exercise are covered in Chapters 22 and 23.
UR - https://www.mendeley.com/catalogue/79ab7067-8558-3c05-8cba-df2ab08dd779/
U2 - 10.1201/9781315373164
DO - 10.1201/9781315373164
M3 - Chapter
SN - 9781482234305
T3 - Glutamine: Biochemistry, Physiology, and Clinical Applications
SP - 293
EP - 314
BT - Glutamine: Biochemistry, Physiology, and Clinical Applications
ER -